Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition

Kim, Bo Yeon; Yoon, Ji Hee; Kim, Myeongbin; Kim, Jae Nyoung; Park, Hwangseo; Ryu, Seong Eon; Lee, Sangku

doi:10.1016/j.bmcl.2019.05.021

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Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition

Kim, Bo Yeon;
Yoon, Ji Hee;
Kim, Myeongbin;
Kim, Jae Nyoung;
Park, Hwangseo;
... Ryu, Seong Eon;
외 1명

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2

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2

초록

Structure based virtual screening attempts to discover DUSP1 inhibitors have yielded a scaffold featuring benzoxazole and acylthiourea pharmacophore. A series of its analogues were synthesized to explore structure activity relationship (SAR) of DUSP1 inhibition.

키워드

Dual specificity phosphatase; Mitogen-activated protein kinase; Enzyme inhibition; Structure activity relationship; Cancer; DUAL-SPECIFICITY PHOSPHATASE; NEGATIVE REGULATOR; KINASES; VHR; ERK

제목: Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition

저자: Kim, Bo Yeon; Yoon, Ji Hee; Kim, Myeongbin; Kim, Jae Nyoung; Park, Hwangseo; Ryu, Seong Eon; Lee, Sangku

DOI: 10.1016/j.bmcl.2019.05.021

발행일: 2019-07

유형: Article

저널명: Bioorganic and Medicinal Chemistry Letters

권: 29

호: 14

페이지: 1746 ~ 1748