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N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule Pathway
- Lee, Kang-Eun;
- Heo, Ji-Eun;
- Kim, Jeong-Mok;
- Hwang, Cheol-Sang
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62초록
Although Na-terminal acetylation (Nt-acetylation) is a pervasive protein modification in eukaryotes, its general functions in a majority of proteins are poorly understood. In 2010, it was discovered that Nt-acetylation creates a specific protein degradation signal that is targeted by a new class of the N-end rule proteolytic system, called the Ac/N end rule pathway. Here, we review recent advances in our understanding of the mechanism and biological functions of the Ac/N-end rule pathway, and its crosstalk with the Arg/N-end rule pathway (the classical N-end rule pathway).
키워드
degron; N-end rule; N-terminal acetylation; proteolysis; ubiquitin; E3 UBIQUITIN LIGASE; SACCHAROMYCES-CEREVISIAE IDENTIFICATION; COENZYME-A REDUCTASE; IN-VIVO; PROTEASOMAL DEGRADATION; ALPHA-ACETYLTRANSFERASE; ENDOPLASMIC-RETICULUM; PROTEIN ACETYLATION; EMERGING FUNCTIONS; CELLULAR-PROTEINS
- 제목
- N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule Pathway
- 저자
- Lee, Kang-Eun; Heo, Ji-Eun; Kim, Jeong-Mok; Hwang, Cheol-Sang
- 발행일
- 2016-03
- 유형
- 정기 학술지(Review)
- 권
- 39
- 호
- 3
- 페이지
- 169 ~ 178