NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides

Youn, So Won; Song, Hyoung Sub; Park, Jong Hyub

doi:10.1039/c3ob42546k

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NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides

Youn, So Won;
Song, Hyoung Sub;
Park, Jong Hyub

Citations

WEB OF SCIENCE

37

Citations

SCOPUS

35

초록

An efficient NHC-catalyzed domino oxidation/oxa-Michael addition reaction of 2-alkenylbenzaldehydes has been developed to afford 3-substituted phthalides bearing a C3-stereogenic center with a broad substrate scope and wide functional group tolerance. The preliminary results of the asymmetric process have been provided as well.

키워드

N-HETEROCYCLIC CARBENE; STETTER-ALDOL-MICHAEL; AROMATIC-ALDEHYDES; ASYMMETRIC-SYNTHESIS; ESTERIFICATION; ALCOHOLS; ORGANOCATALYSIS; HYDROACYLATION; LACTONIZATION; ADDITIONS

제목: NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides

저자: Youn, So Won; Song, Hyoung Sub; Park, Jong Hyub

DOI: 10.1039/c3ob42546k

발행일: 2014-04

유형: Article

저널명: Organic and Biomolecular Chemistry

권: 12

호: 15

페이지: 2388 ~ 2393