Quantitative analysis of the fate of gold nanocages in vitro and in vivo after uptake by U87-MG tumor cells

  • Cho, E.C.; 
  • Zhang, Y.; 
  • Cai, X.; 
  • Moran, C.M.; 
  • Wang, L.V.; 
  • 외 1명
Citations

WEB OF SCIENCE

24
Citations

SCOPUS

28

초록

Not always equal: When a mother cell that contains Au nanocages divides, the nanoparticles are unequally distributed between the two daughter cells. This unequal distribution of nanoparticles as well as their clearance from the cells (see picture) is quantitatively analyzed both in vitro and in vivo using two-photon microscopy and photoacoustic microscopy, respectively.

키워드

biological activity; cell uptake; drug delivery; gold; nanoparticles; Cell uptake; Daughter cells; Gold nanocages; In-vitro; Nanocages; Tumor cells; Two photon microscopy; Bioactivity; Cells; Cytology; Drug delivery; Nanoparticles; Gold; arginyl-glycyl-aspartic acid; arginylglycylaspartic acid; cyclopeptide; drug carrier; gold; metal nanoparticle; oligopeptide; acoustic microscopy; animal; article; brain tumor; cell proliferation; chemistry; human; metabolism; mouse; nude mouse; pathology; time lapse imaging; tumor cell line; xenograft; Animals; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Carriers; Gold; Humans; Metal Nanoparticles; Mice; Mice, Nude; Microscopy, Acoustic; Oligopeptides; Peptides, Cyclic; Time-Lapse Imaging; Transplantation, Heterologous
제목
Quantitative analysis of the fate of gold nanocages in vitro and in vivo after uptake by U87-MG tumor cells
저자
Cho, E.C.; Zhang, Y.; Cai, X.; Moran, C.M.; Wang, L.V.; Xia, Y.
DOI
10.1002/anie.201208096
발행일
2013-01
유형
Article
저널명
Angewandte Chemie International Edition
권
52
호
4
페이지
1152 ~ 1155