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Loss of Calreticulin Uncovers a Critical Role for Calcium in Regulating Cellular Lipid Homeostasis
- Wang, Wen-An;
- Liu, Wen-Xin;
- Durnaoglu, Serpen;
- Lee, Sun-Kyung;
- Lian, Jihong;
- ... Ahnn, Joohong;
- 외 3명
WEB OF SCIENCE
34SCOPUS
39초록
A direct link between Ca2+ and lipid homeostasis has not been definitively demonstrated. In this study, we show that manipulation of ER Ca2+ causes the re-distribution of a portion of the intracellular unesterified cholesterol to a pool that is not available to the SCAP-SREBP complex. The SREBP processing pathway in ER Ca2+ depleted cells remained fully functional and responsive to changes in cellular cholesterol status but differed unexpectedly in basal activity. These findings establish the role of Ca2+ in determining the reference set-point for controlling cellular lipid homeostasis. We propose that ER Ca2+ status is an important determinant of the basal sensitivity of the sterol sensing mechanism inherent to the SREBP processing pathway.
키워드
- 제목
- Loss of Calreticulin Uncovers a Critical Role for Calcium in Regulating Cellular Lipid Homeostasis
- 저자
- Wang, Wen-An; Liu, Wen-Xin; Durnaoglu, Serpen; Lee, Sun-Kyung; Lian, Jihong; Lehner, Richard; Ahnn, Joohong; Agellon, Luis B.; Michalak, Marek
- 발행일
- 2017-07
- 유형
- Article
- 권
- 7
- 호
- 1
- 페이지
- 1 ~ 15