Biopharmaceutical drug delivery system

초록

In recent years, a large number of literatures have disclosed in situ forming biodegradable drug delivery systems that solidify or gel in the tissue, organ or body cavity from injectable fluids, control the release rate of drug for a certain period of time and are progressively degraded and eliminated after a certain period of application times. In situ gels can solve the problems associated with most widely used biodegradable microsphere formulations, such as the drug loss caused by low encapsulation efficiencies of microspheres, the use of harsh organic solvent and manufacturing costs increases by several processes. Definitely, the parenteral delivery including in-situ polymer gels is currently most demanding and suitable for the successful development of recombinant therapeutic proteins by stabilizing and controlling the release rate of sensitive proteins.