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초록
Bcl-2 family proteins are key regulators of apoptosis associated with human disease, including cancer. Bcl-2 protein has been found to be overexpressed in many cancer cells. Therefore, Bcl-2 protein is a potential diagnostic target for cancer detection. In the present study, the authors have identified several Bcl-2 binding peptides with high affinity (picomolar range) from a 5-round M13 phage display library screening. These peptides can be used to develop novel diagnostic probes or potent inhibitors with diverse polyvalencies. (Journal of Biomolecular Screening 2011:82-89)
키워드
cancer; apoptosis; diagnostics probe; Bcl-2 protein-binding peptides; M13 phage display; CELL-DEATH; FAMILY PROTEINS; EPITOPE LIBRARY; GENE FAMILY; CANCER; APOPTOSIS; IDENTIFICATION; SURVIVAL; TUMORIGENESIS; STRATEGIES
- 제목
- Phage Display Screen for Peptides That Bind Bcl-2 Protein
- 저자
- Park, Hye-Yeon; Kim, Joungmok; Cho, June-Haeng; Moon, Ji Young; Lee, Su-Jae; Yoon, Moon-Young
- 발행일
- 2011-01
- 유형
- Article
- 권
- 16
- 호
- 1
- 페이지
- 82 ~ 89