상세 보기
Total Synthesis of (+/-)-Aspidospermidine Starting from 3-Ethyl-5-bromo-2-pyrone
- Cho, Hyun-Kyu;
- Tam, Nguyen Thanh;
- Cho, Cheon-Gyu
Citations
WEB OF SCIENCE
25Citations
SCOPUS
26초록
A new synthetic route to (+/-)-aspidospermidine was devised, starting from the cycloadduct of 3-ethyl-5-bromo-2-pyrone with vinyl sulfide through a tandem conjugate addition-alkylation sequence The requisite 3-ethyl-5-bromo-2-pyrone was prepared via the C3-selective Pd-catalyzed coupling reaction with Et3Al-dimethylaminoethanol complex
키워드
Total synthesis; Aspidospermidine; Diels-Alder reaction; 3,5-Dibromo-2-pyrone; Tandem reaction; INTRAMOLECULAR SCHMIDT REACTION; DIELS-ALDER CYCLOADDITIONS; FORMAL TOTAL SYNTHESIS; ASPIDOSPERMA ALKALOIDS; EFFICIENT SYNTHESIS; COUPLING REACTIONS; ARYL; (+)-ASPIDOSPERMIDINE; (+/-)-CRININE; STRATEGY
- 제목
- Total Synthesis of (+/-)-Aspidospermidine Starting from 3-Ethyl-5-bromo-2-pyrone
- 저자
- Cho, Hyun-Kyu; Tam, Nguyen Thanh; Cho, Cheon-Gyu
- 발행일
- 2010-11
- 유형
- Article
- 권
- 31
- 호
- 11
- 페이지
- 3382 ~ 3384