Total Synthesis of (+/-)-Galanthamine via a C3-Selective Stille Coupling and IMDA Cycloaddition Cascade of 3,5-Dibromo-2-pyrone

Chang, Jay Hyok; Kang, Ho-Ung; Jung, In-Hak; Cho, Cheon-Gyu

doi:10.1021/ol100617u

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Total Synthesis of (+/-)-Galanthamine via a C3-Selective Stille Coupling and IMDA Cycloaddition Cascade of 3,5-Dibromo-2-pyrone

Chang, Jay Hyok;
Kang, Ho-Ung;
Jung, In-Hak;
Cho, Cheon-Gyu

Citations

WEB OF SCIENCE

82

Citations

SCOPUS

91

초록

A new efficient synthetic route to (+/-)-galanthamine was devised by using a tandem C3-selective Stifle coupling-IMDA cascade of 3,5-dibromo-2-pyrone as a key strategy.

키워드

DIELS-ALDER CYCLOADDITIONS; (-)-GALANTHAMINE; (+/-)-CRININE; TANDEM; DRUG

제목: Total Synthesis of (+/-)-Galanthamine via a C3-Selective Stille Coupling and IMDA Cycloaddition Cascade of 3,5-Dibromo-2-pyrone

저자: Chang, Jay Hyok; Kang, Ho-Ung; Jung, In-Hak; Cho, Cheon-Gyu

DOI: 10.1021/ol100617u

발행일: 2010-05

유형: Article

저널명: Organic Letters

권: 12

호: 9

페이지: 2016 ~ 2018

언어: ENG

출판사: AMER CHEMICAL SOC

발행국가: 미국

분량: 3 페이지

ISSN: E 1523-7052
P 1523-7060