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Multifunctional Nanoparticles for Targeted Chemophotothermal Treatment of Cancer Cells
- Lee, Sun-Mi;
- Park, Huiyul;
- Choi, Joung-Woo;
- Park, Young Nyun;
- Yun, Chae-Ok;
- 외 1명
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Drug and heat delivery to tumors by active targeting with Herceptin-conjugated doxorubicin-loaded poly(ethylene glycol)-poly(lactic-co- glycolic acid)-Au half-shell nanoparticles (HER-DOX-PLGA-Au H-S NPs) is more effective than passive targeting with their HER-free counterparts (DOX-PLGA-Au H-S NPs). Thus, on NIR irradiation, higher intratumoral temperatures were reached in tumor-bearing mice that were treated with the HER-conjugated particles (see picture). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
키워드
cancer; chemophotothermal treatment; drug delivery; nanoparticles; DRUG-DELIVERY; HYPERTHERMIA; ENHANCEMENT; NANOSPHERES; ADRIAMYCIN
- 제목
- Multifunctional Nanoparticles for Targeted Chemophotothermal Treatment of Cancer Cells
- 저자
- Lee, Sun-Mi; Park, Huiyul; Choi, Joung-Woo; Park, Young Nyun; Yun, Chae-Ok; Yoo, Kyung-Hwa
- 발행일
- 2011-08
- 유형
- Article
- 권
- 50
- 호
- 33
- 페이지
- 7581 ~ 7586