A practical gold-catalyzed route to 4-substituted oxazolidin-2-ones from N-Boc propargylamines

초록

Au-I-catalyzed cyclization of N-Boc propargylamines into 4-alkylidene oxazolidin-2-ones is described. This modular approach provides access to a variety of nonproteogenic 4-substituted oxazolidinones that are important in asymmetric synthesis and biological applications. The current flexible route is characterized by low catalyst loading, mild conditions, and operational simplicity.

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