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초록
The synthesis of a series of conformationally constrained peptidomimetics containing a 9-to-13-atom-membered ring by ring-closing metathesis (RCM) is described. The second-generation Grubbs catalyst proved to be the most effective in producing the desired cyclic beta-peptidomimetics with moderate to good yields. Reaction characteristics such as the influence of alkene chain length in the precursors, position of double bond and ring size of products were also discussed.
키워드
beta-amino acid; macrocyclization; metathesis; peptidomimetics; HELICAL SECONDARY STRUCTURE; AMINO-ACIDS; OLEFIN METATHESIS; STAPLED PEPTIDES; LACTAMS; DESIGN
- 제목
- Synthesis of Macrocyclic beta-Peptidomimetics by Ring-Closing Metathesis
- 저자
- Tran, Dinh Hieu; Nguyen, Xuan Tu; Tran, Thi Minh Chau; Le, Thuy Quynh; Oh, Chang Ho; Mac, Dinh Hung
- 발행일
- 2020-10
- 유형
- Article
- 저널명
- CHEMISTRYSELECT
- 권
- 5
- 호
- 39
- 페이지
- 12232 ~ 12235