Synthetsis and Characterization of Multifunctional Hybrid Silica Particles

초록

Monodisperse, spherical particles with sub-micron size have attracted great attention due to their scientific and industrial applications such as catalysis, medical diagnostics, drug delivery, electronics, and photonic crystals.1,2,3 In addition to their size-dependent properties, several attempts have been made to endow an additional functionality to colloidal particles, including core-shell synthesis, layer-by-layer (LbL) techniques, multi-block copolymer emulsification methods, and surface modification.4,5 Compared to conventional particles with no or single functionality, multifunctional particles have several advantageous characteristics such as multiplex detecting, simultaneous targeting, and etc. However, there has been no report on homogenous multifunctional hybrid particles so far. In this study, de describe a facile synthetic method for multifunctional hybrid silica particles with uniform size and distribution. Multifunctional hybrid silica particles with thiol, vinyl, amine, phenyl, epoxy, isocyanate, and methyl-methacrylate groups could be easily prepared by controlling the hydrolysis and condensation rate of organo-silane mixture. The reaction between surface functional groups of particles and foreign organic molecules extends the surface functionality of multifunction hybrid particles. The distribution of surface functionalities on the particles was investigated using the selective dyes such as fluroescamine and rhodamine red. Thermal analysis of multifunctional hybrid particles also exhibited multiple decomposition patterns from different functional groups in the particles.