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Naphthylpyridyl-Cu(II)-Catalyzed Oxidative Coupling of 2-Naphthylamines to Access BINAM Derivatives
Naphthylpyridyl–Cu(II)-Catalyzed Oxidative Coupling of 2-Naphthylamines to Access BINAM Derivatives
- Lee, Jonghyeon;
- Lee, Jooyeon;
- Kong, Minwoo;
- Kang, Jiwon;
- Lee, Daeyeon;
- ... Lee, Jeonghyo;
- 외 2명
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1초록
In this study, we report the efficient synthesis of 1,1 '-binaphthyl-2,2 '-diamine (BINAM) derivatives via copper-catalyzed oxidative coupling of 2-aminonaphthalenes. The use of a ligand featuring an extended pi system in combination with Cu(II) and molecular oxygen as the terminal oxidant enabled the formation of various BINAM derivatives in yields of up to 84%. Mechanistic investigations suggest a redox pathway involving Cu(II)/Cu(I) cycling, and pi-pi interactions between the ligand and substrate are proposed to stabilize reactive intermediates, thereby contributing to the observed efficiency.
키워드
2 Naphthylamine; Copper; Oxygen; 2 Naphthylamine; Copper; Cupric Ion; Diamine; Oxygen; Article; Catalysis; Controlled Study; Drug Development; Nonhuman; Oxidative Coupling; Synthesis; FACILE SYNTHESIS; COMPLEXES; LIGANDS; ACID; HYDROGENATION; ACTIVATION
- 제목
- Naphthylpyridyl-Cu(II)-Catalyzed Oxidative Coupling of 2-Naphthylamines to Access BINAM Derivatives
- 제목 (타언어)
- Naphthylpyridyl–Cu(II)-Catalyzed Oxidative Coupling of 2-Naphthylamines to Access BINAM Derivatives
- 저자
- Lee, Jonghyeon; Lee, Jooyeon; Kong, Minwoo; Kang, Jiwon; Lee, Daeyeon; Lee, Jeonghyo; Kim, Min; Kang, Houng
- 발행일
- 2025-08
- 유형
- Article; Early Access
- 저널명
- Organic Letters
- 권
- 27
- 호
- 33
- 페이지
- 9195 ~ 9200