Rhodium-Catalyzed Domino Conjugate Addition-Cyclization Reactions for the Synthesis of a Variety of N- and O-Heterocycles: Arylboroxines as Effective Carbon Nucleophiles

Park, Ja Ock; Youn, So Won

doi:10.1021/ol100610v

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Rhodium-Catalyzed Domino Conjugate Addition-Cyclization Reactions for the Synthesis of a Variety of N- and O-Heterocycles: Arylboroxines as Effective Carbon Nucleophiles

Park, Ja Ock;
Youn, So Won

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WEB OF SCIENCE

36

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SCOPUS

41

초록

Facile and efficient Rh(I)-catalyzed domino conjugate addition-cyclization reactions of olefins bearing two electrophilic sites and a pendant nucleophile with organoboroxines have been developed to afford a variety of N- and O-heterocycles, such as 3,4-dihydroquinolin-2(1H)-ones, 3,4-dihydrocoumarins, and pyrrolidin-2-ones, which constitute important motifs in biologically active natural and synthetic organic compounds.

키워드

PICTET-SPENGLER REACTION; SEQUENTIAL C-C; ASYMMETRIC 1,4-ADDITION; ENANTIOSELECTIVE SYNTHESIS; ALKENYLBORONIC ACIDS; FACILE CONSTRUCTION; BOND FORMATIONS; REAGENTS; PHENOLS; DIENES

제목: Rhodium-Catalyzed Domino Conjugate Addition-Cyclization Reactions for the Synthesis of a Variety of N- and O-Heterocycles: Arylboroxines as Effective Carbon Nucleophiles

저자: Park, Ja Ock; Youn, So Won

DOI: 10.1021/ol100610v

발행일: 2010-05

유형: Article

저널명: Organic Letters

권: 12

호: 10

페이지: 2258 ~ 2261