미숙아에서 정맥 영양 내 아미노산 공급량의 변화가 간기능에 미치는 영향

초록

Purpose : To study the safety of more aggressive parenteral amino acid supplementation on liver functions during parenteral nutrition in preterm infants. Methods : Medical records of preterm infants (n=58) treated in the neonatal intensive care unit from 2004through 2008 with birth weight less than 2,000 g and exposure to parenteral nutrition (PN) for more than 7 days were reviewed. Patients were divided into two groups; low amino acid intake group (LAA, n=32) admitted from January 2004 to May 2006 and high amino acid intake group (HAA, n=26) admitted from June 2006to July 2008. The incidence of cholestasis was compared between the two groups and the liver functions in infants with cholestasis were evaluated. Results : Mean protein intake was significantly higher in HAA (1.0±0.2 g/kg/day vs 2.1±0.6 g/kg/day,P=0.001). But there were no differences in the incidence and duration of cholestasis between the groups. And peak total bilirubin (T.bil), peak direct bilirubin (D.bil), peak alanine aminotransferase (ALT), peak asparate aminotransferase (AST), and peak alkaline phosphatase (ALP) in infants with cholestasis were not significantly different. Conclusion : Aggressive parenteral amino acid supplementation in preterm infants were not associated significantly with the liver functions in this study.

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