2018-2021년에 분리된 Corynebacterium striatum의 항균제 감수성 양상과 임상적 특성

초록

Background: Corynebacterium striatum is part of the normal flora of the skin, oral cavity,and intestine. However, it can be a pathogen causing endocarditis, pneumonia, arthritis, andmeningitis occasionally. We evaluated the clinical features and antimicrobial susceptibilitypattern of C. striatum cases. Methods: Patients infected with C. striatum, who consulted infectious disease physicians andwere admitted to Hanyang University hospital between January 2018 and January 2021, wereenrolled for an antimicrobial susceptibility test (AST). We reviewed medical records of selectedpatients for information on diagnosis, specimen types, and antibiotics used before and afterAST. AST was performed using E-test and interpreted according to the Clinical and LaboratoryStandards Institute M45 guidelines. Results: A total of 23 cases were evaluated, and average age of patients was 58.5 years. Tencases were diagnosed sepsis. Eight cases were complicated with cancer, and five cases hadwound infections. Four cases were treated with vancomycin prior to AST; in 13 cases, antibioticswere switched to vancomycin after AST. Resistance rates were highest for ciprofloxacin(93.3%), which was followed by cefotaxime (92.3%), penicillin G (87.0%), erythromycin (87.0%),trimethoprim/sulfamethoxazole (78.3%), and meropenem (76.5%). Conclusion: The patients infected by C. striatum were old and immunosuppressed, while manyhad cancer. Since C. striatum shows resistance to most drugs except vancomycin, we shouldconsider conducting AST prior to antibiotic treatment.

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