고지방식이유도 비만 마우스를 이용한 귀리 혼합 잡곡의 항비만 효능

초록

Obesity is an epidemic, contributing to metabolic diseases such as type 2 diabetes, dyslipidemia, and cardiovascular conditions. Oats (Avena sativa) have become a potential superfood in Korea. Male C57BL/6NTac mice were fed a mixed diet of a high-fat diet (45% kcal from fat) and multi-grain powder for 20 weeks. Samples were prepared by varying the amount of oats to 0 (w/w), 10, 20, 30, and 40%, respectively, based on white rice and three kinds of basic grains (brown rice, black bean and barley). The multi-grain was cooked, freeze-dried, and powdered. Oat supplementation did not affect adiposity, including body weight and fat accumulation. Parameters such as feed efficiency, liver weight, hepatic triglycerides, serum triglycerides, and total cholesterol were unchanged. Inflammation markers and antioxidant capacity also showed no significant differences. Furthermore, oats did not improve oral glucose tolerance or fasting blood glucose levels. Therefore, multi-grain fortified with oat did not provide anti-obesity effects or benefits for metabolic syndromes in high-fat diet-induced obesity in mice.

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