Improving Participation in Clinical Trials of Novel Therapies: Going Back to Basics

Choi, Chan-Bum; Bae, Sang-Cheol; Gupta, Samar; Rogers, Malcolm P.; Liang, Matthew H.

doi:10.1016/j.rdc.2014.05.002

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Improving Participation in Clinical Trials of Novel Therapies: Going Back to Basics

Choi, Chan-Bum;
Bae, Sang-Cheol;
Gupta, Samar;
Rogers, Malcolm P.;
Liang, Matthew H.

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4

초록

Clinical trials in many diseases are experiencing'more difficulties in achieving sufficient or timely enrollment of participants; anecdotal reports from trials of novel therapies for systemic lupus erythematosus (SLE) seem to be facing the same challenges. General factors associated with this trend include the growth of the contract research industry, increasing oversight, and high-profile accounts of scientific misconduct and fraud in research. Complicated protocols that increase participant burden, overly restrictive entry criteria, the fear of an SLE flare may also affect enrollment in SLE trials.

키워드

Systemic lupus erythematosus; Randomized clinical trials; Enrollment; Retention; RECRUITMENT; PREVENTION; CONSENT; SLE

제목: Improving Participation in Clinical Trials of Novel Therapies: Going Back to Basics

저자: Choi, Chan-Bum; Bae, Sang-Cheol; Gupta, Samar; Rogers, Malcolm P.; Liang, Matthew H.

DOI: 10.1016/j.rdc.2014.05.002

발행일: 2014-08

유형: Article

저널명: Rheumatic Disease Clinics of North America

권: 40

호: 3

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