CELL-SPECIFIC SIRNA DELIVERY BY PEPTIDES AND ANTIBODIES

Lee, Sang-Kyung; Siefert, Alyssa; Beloor, Jagadish; Fahmy, Tarek M.; Kumar, Priti

doi:10.1016/B978-0-12-416039-2.00005-7

상세 보기

CELL-SPECIFIC SIRNA DELIVERY BY PEPTIDES AND ANTIBODIES

Lee, Sang-Kyung;
Siefert, Alyssa;
Beloor, Jagadish;
Fahmy, Tarek M.;
Kumar, Priti

Citations

WEB OF SCIENCE

24

Citations

SCOPUS

23

초록

Cellular targeting and intracellular delivery of small interfering RNA (siRNA) remain a critical barrier to the clinical application of RNA interference. This chapter provides an overview of various delivery agents employing protein ligands mediating cell-specific delivery of siRNA. Specifically, the chapter details methodologies for the conjugation of antibody or peptide ligands to 0 the cationic peptide-oligo-9-arginine (ii) the polymer poly(lactic-co-glycolic acid) (PLGA) and (iii) a lipid-vesicle (Liposome).

키워드

cationic peptide; liposome; siRNA delivery; Small interfering RNA; targeted delivery; SMALL-INTERFERING RNA; TARGETED DELIVERY; PLGA NANOPARTICLES; NANO-CARRIERS; GENE DELIVERY; EFFICIENT; LIPOSOMES; SURFACE; NANOSPHERES; POLYESTERS

제목: CELL-SPECIFIC SIRNA DELIVERY BY PEPTIDES AND ANTIBODIES

저자: Lee, Sang-Kyung; Siefert, Alyssa; Beloor, Jagadish; Fahmy, Tarek M.; Kumar, Priti

DOI: 10.1016/B978-0-12-416039-2.00005-7

발행일: 2012-02

유형: Review; Book Chapter

저널명: Methods in Enzymology

권: 502

페이지: 91 ~ 122