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Interleukin-6-Mediated Induced Pluripotent Stem Cell (iPSC)-Derived Neural Differentiation
- Sulistio, Yanuar Alan;
- Lee, Han Kyu;
- Jung, Sung Jun;
- Heese, Klaus
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14초록
In an aging society with an increasing threat to higher brain cognitive functions due to dementia, it becomes imperative to identify new molecular remedies for supporting adult neurogenesis. Interleukin-6 (IL-6) is a promising cytokine that can support neurogenesis under conditions of neurodegeneration, and neuron replacement is eventually possible due to its agonistic acting soluble receptor sIL-6R. Here, we report that activation of the IL-6-signal transducer and activator of transcription 3 (STAT3) axis is neurogenic and has potential therapeutic applications for the treatment of neurodegenerative diseases such as Parkinson's disease (PD).
키워드
BDNF; Brain; Interleukin-6; Neuron; Neurotrophin; STAT3; PROMOTES NEURONAL DIFFERENTIATION; LEUKEMIA INHIBITORY FACTOR; CENTRAL-NERVOUS-SYSTEM; PC12 CELLS; DOPAMINERGIC-NEURONS; NEURITE OUTGROWTH; PROGENITOR CELLS; PARKINSONS-DISEASE; ASTROCYTIC DIFFERENTIATION; FUNCTIONAL RECOVERY
- 제목
- Interleukin-6-Mediated Induced Pluripotent Stem Cell (iPSC)-Derived Neural Differentiation
- 저자
- Sulistio, Yanuar Alan; Lee, Han Kyu; Jung, Sung Jun; Heese, Klaus
- 발행일
- 2018-04
- 유형
- Article
- 권
- 55
- 호
- 4
- 페이지
- 3513 ~ 3522