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Total Syntheses of Ningalins D and G
- Kim, Jang-Yeop;
- Kim, Dong-Hyun;
- Jeon, Tae-Hong;
- Kim, Woo-Hyung;
- Cho, Cheon-Gyu
Citations
WEB OF SCIENCE
22Citations
SCOPUS
24초록
A flexible synthetic strategy for the total syntheses of ningalins D and G is described. The highly effective TMS-OTf/2,6-lutidine-mediated [3,3]-sigmatropic rearrangement of densely loaded dinaphthyl hydrazides and cyclization of the resulting 2,2'-diamino-1,1'-dinaphthyls afforded the key 7H-dibenzo[c,g]carbazole intermediates. Successful conversions to biphenylene quinone methides followed by regioselective brominations completed the total syntheses of the titled marine alkaloids.
키워드
FISCHER INDOLE SYNTHESIS; METHYL ARENES; ALKALOIDS; REARRANGEMENT; HYDRAZIDES; ACID; BROMINATION; LAMELLARINS; COMBINATION; IODINATION
- 제목
- Total Syntheses of Ningalins D and G
- 저자
- Kim, Jang-Yeop; Kim, Dong-Hyun; Jeon, Tae-Hong; Kim, Woo-Hyung; Cho, Cheon-Gyu
- 발행일
- 2017-09
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 19
- 호
- 17
- 페이지
- 4688 ~ 4691