Be cautious applying carbon-fluorine bonds in drug delivery

  • Sonne, Christian
  • Lam, Su Shiung
  • Kim, Ki-Hyun
  • Rinklebe, Joerg
  • Ok, Yong Sik
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초록

As reported in Chemosphere by Colles et al. (2020), there are multiple pathways for human exposure to poly- and perfluoroalkyl substances (PFAS). Now, a new chemical formation of C-F bonds in drug delivery lead to concerns for human exposure as these inert chemical formations are resistance to metabolic degradation and excretion.

키워드

carboncholesteroldrinking waterfluorinethiomersalcarbonfluoridefluorinefluorocarbonadverse eventchemical analysischemical bonddegradation kineticsdrug delivery systemdrug excretiondrug exposuredrug safetydrug structureevidence based practicehalf life timehumankidney cancermaternal hypertensionneurotoxicityNotepregnant womantestis cancerthyroid diseasetoxicity testingulcerative colitisvaccine productionchemistry
제목
Be cautious applying carbon-fluorine bonds in drug delivery
저자
Sonne, ChristianLam, Su ShiungKim, Ki-HyunRinklebe, JoergOk, Yong Sik
DOI
10.1016/j.chemosphere.2020.125971
발행일
2020-06
유형
Editorial Material
저널명
Chemosphere
248
페이지
1 ~ 2