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Water intoxication following low-dose intravenous cyclophosphamide
- Tai, Yeon Ko;
- Bae, Sang-Cheol;
- Park, Joon Sung;
- Chang, Hwa Lee;
- Moon, Hyang Park;
- 외 2명
Citations
SCOPUS
11초록
Cyclophosphamide is frequently used for the treatment of severe lupus nephritis, but is very rarely associated with dilutional hyponatremia. Recently we experienced a case of water intoxication following low-dose intravenous cyclophosphamide. Five hours after one dose of intravenous pulse cyclophosphamide 750 mg, the patient developed nausea, vomiting, and general weakness. Serum sodium concentration revealed 114 mEq/L and her hyponatremia was initially treated with hypertonic saline infusion. Then her serum sodium concentration rapidly recovered to normal with water restriction alone. During the course of intravenous pulse cyclophosphamide therapy, one must be aware of the possibility of significant water retention.
키워드
Cyclophosphamide; Hyponatremia; Lupus nephritis; Water intoxication; azathioprine; cyclophosphamide; hydroxychloroquine; prednisolone; sodium; sodium chloride; adult; article; blood pressure; case report; female; histopathology; human; human tissue; hyponatremia; kidney biopsy; low drug dose; nausea; side effect; systemic lupus erythematosus; vomiting; water intoxication; weakness
- 제목
- Water intoxication following low-dose intravenous cyclophosphamide
- 저자
- Tai, Yeon Ko; Bae, Sang-Cheol; Park, Joon Sung; Chang, Hwa Lee; Moon, Hyang Park; Chong, Myung Kang; Kim, Gheun Ho
- 발행일
- 2007-06
- 유형
- Article
- 권
- 5
- 호
- 1
- 페이지
- 50 ~ 54