전기방사를 통한 Hydroxyapatite/Silk Fibroin 복합체의 제조

초록

The organic-inorganic hybrids have both the advantages of organic materials, such as light weight, flexibility and good moldability, and inorganic materials, such as high strength, heat stability and chemical resistance. Electrospinning is a simple and versatile method for generating ultrathin fibers from a rich variety of materials that include polymers, composites and ceramics. Silk fibroin(SF) is one of the most desirable biomaterials because of its biocopatibility and higher mechanical properties comparing to other protein fiber. Hydroxyapatite(HAp) is also a very promising candidate because of its excellent biocompatibility and nontoxic hypostasis with organic tissues and its adsorbability of bacteria and replication competent human virus. However, HAp is so brittle that it is difficult to prepare any form except particle. In the past studies, HAp/polymer composites were prepared by dispersing HAp in polymer solution or using SBF(Simulated Body Fluid). In this study, SF/HAp composites were fabricated by padding HAp on electrospun SF web and characterized.