Synthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy

Moon, Byung Seok; Park, Moon-Taek; Park, Jeong Hoon; Kim, Sang Wook; Lee, Kyo Chul; An, Gwang Il; Yang, Seung Dae; Chi, Dae Yoon; Cheon, Gi Jeong; Lee, Su-Jae

doi:10.1016/j.bmcl.2007.09.037

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Synthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy

Moon, Byung Seok;
Park, Moon-Taek;
Park, Jeong Hoon;
Kim, Sang Wook;
Lee, Kyo Chul;
외 5명

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4

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4

초록

Eight D-ribo-phytosphingosine derivatives were synthesized from D-ribo-phytosphingosine and diverse acyl chlorides with N,N-diisopropylethylamine in tetrahydrofuran for 1 h at room temperature. Effect of these compounds on IR-induced cell death was evaluated on blood cancer cells (Jurkat). Among these, 3d showed the highest enhancement of radiosensitizing effect.

키워드

Phytoceramide; Phytosphingosine; Radiosensitizer; Sphingolipids; RESISTANT CANCER-CELLS; CONCURRENT RADIATION; IONIZING-RADIATION; LUNG-CANCER; IN-VITRO; TAXOL; COMBINATION; PACLITAXEL; CERAMIDES; RADIOTHERAPY

제목: Synthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy

저자: Moon, Byung Seok; Park, Moon-Taek; Park, Jeong Hoon; Kim, Sang Wook; Lee, Kyo Chul; An, Gwang Il; Yang, Seung Dae; Chi, Dae Yoon; Cheon, Gi Jeong; Lee, Su-Jae

DOI: 10.1016/j.bmcl.2007.09.037

발행일: 2007-12

유형: Article

저널명: Bioorganic and Medicinal Chemistry Letters

권: 17

호: 23

페이지: 6643 ~ 6646