Emission and Cytotoxicity of Surgical Smoke: Cholesta-3,5-Diene Released from Pyrolysis of Prostate Tissue

초록

Respiratory and lung irritants can be a by-product of the surgical pyrolysis of human tissues. Seven prostate tissues were collected during the transurethral resection of a prostate (TURP). Tissue samples, pyrolyzed in a pyrolysis sampling system, were collected and analyzed for the characterization of aerosols in the surgical smoke. In the pyrolyzed particulate matter (PM) from the TURP, Cholestra-3,5-diene was identified as the most dominant component along with 9-methylanthracene, hentriacontane, and dotriacontane based on the mass fragment structure determined using gas chromatography-mass spectrometry (GC-MS). As a molecular marker, Cholesta-3,5-diene can be associated with a cytotoxic in primary human oral keratinocytes (HOK). In this research, the presence of Cholestra-3,5-diene is reported for the first time as a by-product of surgical pyrolysis.

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