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저용량 adefovir dipivoxil에 의한 저인산염혈증과 다발성 근육통 1예
- 유기덕;
- 정종헌;
- 조수경;
- 김근호;
- 최호순;
- ... 전재범;
- 외 1명
초록
Adefovir dipivoxil (ADV) effectively inhibits lamivudine-resistant hepatitis B virus replication. Hypophosphatemia and elevated serum creatinine are ADV-related nephrotoxicity caused by high-dose ADV. Hypophosphatemic osteomalacia is very rare and is induced by low-dose ADV. A 61-year-old man suffering from chronic hepatitis B manifested with generalized myalgia and bone pain, especially in both ankles and knees. He had been administered ADV for 56 months, since lamivudine-resistant HBV was detected. He developed severe hypophosphatemia and elevated serum alkaline phosphatase levels with a high bone fraction. Bone densitometry and a whole-body bone scan revealed osteoporosis and multiple hot uptake lesions. Blood chemistry and clinical symptoms improved after discontinuing the ADV.
키워드
- 제목
- 저용량 adefovir dipivoxil에 의한 저인산염혈증과 다발성 근육통 1예
- 제목 (타언어)
- A case of hypophosphatemic osteomalacia associated with low-dose adefovir dipivoxil treatment
- 저자
- 유기덕; 정종헌; 조수경; 김근호; 최호순; 김동선; 전재범
- 발행일
- 2010-02
- 저널명
- 대한내과학회지
- 권
- 78
- 호
- 2
- 페이지
- 261 ~ 265