Asymmetric Total Syntheses of (-)-Ervatamine and (+)-19,20-Dehydroervatamine via Late-Stage Directed Indolization

Chen, Qinyang; Jeon, Da-Yun; Cho, Cheon-Gyu

doi:10.1021/acs.orglett.5c01430

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Asymmetric Total Syntheses of (-)-Ervatamine and (+)-19,20-Dehydroervatamine via Late-Stage Directed Indolization

Chen, Qinyang;
Jeon, Da-Yun;
Cho, Cheon-Gyu

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초록

Asymmetric total syntheses of (-)-ervatamine and (+)-19,20-dehydroervatamine are described. The key is the directed, late-stage implementation of the indole unit, enabled by the strategically installed ketone group in the central cycloheptene ring.

키워드

FISCHER INDOLE SYNTHESIS; STEREOCONTROLLED SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; ERVATAMIA-ORIENTALIS; GENERAL STRATEGY; ALKALOIDS; REARRANGEMENT; COMBINATION; POTENT

제목: Asymmetric Total Syntheses of (-)-Ervatamine and (+)-19,20-Dehydroervatamine via Late-Stage Directed Indolization

저자: Chen, Qinyang; Jeon, Da-Yun; Cho, Cheon-Gyu

DOI: 10.1021/acs.orglett.5c01430

발행일: 2025-07

유형: Article; Early Access

저널명: Organic Letters

권: 27

호: 29

페이지: 7744 ~ 7749