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초록
Synthetic routes leading to [6,6,6]-tricyclic compounds were reported using metal catalysts from ene-yne-aldehydes in our group. Based on this result, the synthesis of various [6,6,6]-tricyclic compounds is reported using transition metal-catalyzed cyclization from enyne-carbonyl substrates containing H, Me, Ph, OMe, CO2Me, and CO(2)i-Pr groups. Tricyclic compounds containing the CO2Me group would be the prospective precursors of the natural product Lepenine.
키워드
[6; 6; 6]-tricyclic compound; copper catalyst; cycloisomerization; enyne-carbonyl; Lepenine precursor; DITERPENOID ALKALOIDS; GOLD; DERIVATIVES; CYCLOADDITION; PHENANTHRENES; ANNULATION; ENYNALS; ROUTE
- 제목
- Intramolecular Cyclization of 2-Alkynylphenylcarbonyls With a Pendant Double Bond under Copper Catalysis: A General Approach to Norabietane Core Structure
- 저자
- Kang, Juyeon; Lee, Ju Hui; Lee, Junseong; Oh, Chang Ho
- 발행일
- 2022-07
- 유형
- Article; Early Access
- 권
- 11
- 호
- 7
- 페이지
- 1 ~ 6