RanBPM: a potential therapeutic target for modulating diverse physiological disorders

Das, Soumyadip; Suresh, Bharathi; Kim, Hyongbum (Henry); Ramakrishna, Suresh

doi:10.1016/j.drudis.2017.08.005

상세 보기

RanBPM: a potential therapeutic target for modulating diverse physiological disorders

Das, Soumyadip;
Suresh, Bharathi;
Kim, Hyongbum (Henry);
Ramakrishna, Suresh

Citations

WEB OF SCIENCE

9

Citations

SCOPUS

10

초록

The Ran-binding protein microtubule-organizing center (RanBPM) is a highly conserved nucleocytoplasmic protein involved in a variety of intracellular signaling pathways that control diverse cellular functions. RanBPM interacts with proteins that are linked to various diseases, including Alzheimer's disease (AD), schizophrenia (SCZ), and cancer. In this article, we define the characteristics of the scaffolding protein RanBPM and focus on its interaction partners in diverse physiological disorders, such as neurological diseases, fertility disorders, and cancer.

키워드

BINDING-PROTEIN RANBPM; MICROTUBULE-ORGANIZING CENTER; AMYLOID PRECURSOR PROTEIN; BETA PEPTIDE GENERATION; SCAFFOLDING PROTEIN; ALZHEIMERS-DISEASE; RANBP9-COFILIN PATHWAY; INTERACTING PROTEIN; TUMOR-SUPPRESSOR; CELL-MIGRATION

제목: RanBPM: a potential therapeutic target for modulating diverse physiological disorders

저자: Das, Soumyadip; Suresh, Bharathi; Kim, Hyongbum (Henry); Ramakrishna, Suresh

DOI: 10.1016/j.drudis.2017.08.005

발행일: 2017-12

유형: Review

저널명: Drug Discovery Today

권: 22

호: 12

페이지: 1816 ~ 1824