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Highly diastereoselective type-I IMDA reaction forming medium-sized macrolactones
- Shin, Jeong-Taek;
- Hong, Sung-Cho;
- Shin, Seunghoon;
- Cho, Cheon-Gyu
Citations
WEB OF SCIENCE
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SCOPUS
20초록
Intramolecular Diels-Alder (IMDA) reactions of 2-pyrones containing an alkyne tether occur with remarkably high diastereofacial selectivity to provide medium-sized macrolactones. Because of the strain in the alkyne-tethered macrocyclic system, a single methyl group in the tether provides sufficient conformational bias to generate medium-sized macrocycles with unusually high selectivity.
키워드
DIELS-ALDER CYCLOADDITIONS; STILLE COUPLING REACTIONS; ASYMMETRIC-SYNTHESIS; 3,5-DIBROMO-2-PYRONE; PATHWAYS; ACCESS; ARYL
- 제목
- Highly diastereoselective type-I IMDA reaction forming medium-sized macrolactones
- 저자
- Shin, Jeong-Taek; Hong, Sung-Cho; Shin, Seunghoon; Cho, Cheon-Gyu
- 발행일
- 2006-07
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 8
- 호
- 15
- 페이지
- 3339 ~ 3341