성공적인 당뇨병 치료를 위한 유전자 전달 기술을 이용한 췌장 소도 세포 이식

초록

This review will be discussed about cognizance of diabetes and diabetes therapy according to aging society. Becoming aging society, diabetes is the 4th leading cause of death of aged 65 and older. Thus, treatment of diabetes is needed. Typical treatment is an insulin injection. However, insulin injections can cause hypoglycemia, and patient feel uncomfortable. The ideal way is pancreatic islet transplantation that can simultaneously control glucose. However this method has several problems such as lack of contributors, transplanted islets are rapidly eliminated from the body because of rare islet engraftment, hypoxia, and islet graft rejection. Among them, hypoxia-indued islet death is main issue. Thus, it is necessary to develop the remedy for successful pancreatic islet transplantation without hypoxia induction. This review summarized that gene delivery such as Heme oxygenase-1 (HO-1), Vascular endothelial growth factor (VEGF) could protect the transplanted islets from hypoxia.

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