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Total Synthesis of (-)-Neocosmosin A via Intramolecular Diels-Alder Reaction of 2-Pyrone
- Lee, Joon-Ho;
- Cho, Cheon-Gyu
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WEB OF SCIENCE
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SCOPUS
30초록
A new synthetic route to (-)-neocosmosin A was devised by elaboration, of intramolecular Diels- Alder (IMDA) cycloaddition of 2-pyrone containing a bromopropiolate group as the dienophile. The IMDA reaction was accompanied by cycloreversion of carbon dioxide to give benzannulated macrolide with two bromide groups at C14 and C16. Installation of the pinacolboryl groups and oxidations allowed completion of the total synthesis of (-)-neocosmosin A.
키워드
RESORCYLIC ACID LACTONES; REGIOSELECTIVE SYNTHESIS; 3,5-DIBROMO-2-PYRONE; BIOSYNTHESIS; CHEMISTRY; (E)-BETA-BORYLSTYRENE; CYCLOADDITIONS; MACROLACTONES; (+/-)-CRININE; NEOCOSMOSIN
- 제목
- Total Synthesis of (-)-Neocosmosin A via Intramolecular Diels-Alder Reaction of 2-Pyrone
- 저자
- Lee, Joon-Ho; Cho, Cheon-Gyu
- 발행일
- 2016-10
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 18
- 호
- 19
- 페이지
- 5126 ~ 5129