Expression of activated HER2 in human testes

Shin, Inchoel; Kim, Hyun Joo; Nah, Won Heum; Park, Hyun Jun; Gye, Myung Chan; Park, Hae Young

doi:10.1016/j.fertnstert.2011.04.043

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Expression of activated HER2 in human testes

Shin, Inchoel;
Kim, Hyun Joo;
Nah, Won Heum;
Park, Hyun Jun;
Gye, Myung Chan;
외 1명

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5

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SCOPUS

6

초록

The her2 messenger RNA (mRNA) was the most abundant among the erb type-1 tyrosine kinase receptors mRNA in human testis and was statistically significantly decreased in impaired spermatogenesis. Testicular HER2 was tyrosine phosphorylated and strongly expressed in spermatogonia, early spermatocytes, elongating/elongated spermatids, Sertoli cells, Leydig cells, and peritubular cells, suggesting that activated HER2 participates in mitosis and meiotic entry of germ cells, spermiogenesis, and steroidogenesis via mediating the epidermal growth factor-growth factor signaling.

키워드

Germ cells; HER2; human; soma; testis; tyrosine phosphorylated; EPIDERMAL-GROWTH-FACTOR; BREAST-CANCER; LEYDIG-CELLS; RECEPTOR; LOCALIZATION; NETWORK; ERBB-2

제목: Expression of activated HER2 in human testes

저자: Shin, Inchoel; Kim, Hyun Joo; Nah, Won Heum; Park, Hyun Jun; Gye, Myung Chan; Park, Hae Young

DOI: 10.1016/j.fertnstert.2011.04.043

발행일: 2011-06

유형: Editorial Material

저널명: Fertility and Sterility

권: 95

호: 8

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