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임상적으로 호전된 진행다초점백질뇌병증 환자의 백질 내 해부학적 연결성 추적관찰
Serial Follow-up of White Matter Connectivity in a Patient with Progressive Multifocal Leukoencephalopathy Presenting Clinical Improvement
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초록
Progressive multifocal leukoencephalopathy (PML) is a fatal disease that is characterized by progressive demyelination of the cerebral white matter due to JC viral infection. We report serial magnetic resonance spectroscopy (MRS) and tractography changes in a patient with PML. After a three-cycle treatment with cidofovir and cytarabine, the patient exhibited remarkable improvements in motor and cognitive functions. Follow-up MRS and tractography revealed regeneration of the white-matter fibers. This is the first consecutive neuroimaging study showing improvements in neurological symptoms using MRS and tractography.
키워드
Key Words: Progressive multifocal leukoencephalopathy; Magnetic resonance spectroscopy; Tractography; Key Words: Progressive multifocal leukoencephalopathy; Magnetic resonance spectroscopy; Tractography
- 제목
- 임상적으로 호전된 진행다초점백질뇌병증 환자의 백질 내 해부학적 연결성 추적관찰
- 제목 (타언어)
- Serial Follow-up of White Matter Connectivity in a Patient with Progressive Multifocal Leukoencephalopathy Presenting Clinical Improvement
- 저자
- 정단일; 오성일; 오경필; 백원기; 김희진; 김승현
- 발행일
- 2011-05
- 저널명
- 대한신경과학회지
- 권
- 29
- 호
- 4
- 페이지
- 347 ~ 351