MULTI-FUNCTIONAL HYBRID SILICA PARTICLES FOR NITROGEN CHEMOSENSORS

초록

In the last decade there has been an increasing interest in the development of optical chemosensor for covalent interactions with target molecules. Among the various types of sensory materials, functionalized organic-inorganic hybrid particles have received great attention due to their easy preparation, detection mobility, and signal amplification. However, as demands on multiplex detecting, simultaneous targeting/separation, and etc. arose recently, the development of multifuntional materials has been the center of leading research topics. In this study, we have prepared multi-functional hybrid silica particles for simultaneous targeting, detecting, and anchoring to various substrates. In addition, the surface property of this hybrid particles can be adjusted to hydrophilic or hydrophilic just by changing one of functional groups in the particle. Using modified sol-gel process multi-functional hybrid silica particles with phenyl/vinyl, thiol, and amine functionalities were synthesized first. In order to endow substrate binding ability, the amine functional groups on the surface of hybrid particles were then converted to carboxylic acid moieties through surface reaction with glutaric anhydride. Thiol groups on the surface of hybrid particles were also modified with o-phthaladehyde(OPA) for the detection of amine groups. By monitoring fluorescence spectrum of isoindole product resulting from covalent bonding between OPA on the surface of hybrid particles and external amine groups,the sensing characteristics of multi-functional hybrid silica particles have been studied.