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초록
Expression of claudin-11, which builds up blood-testis barrier (BTB), was increased in decreased spermatogenesis, including in hypospermatogenesis, spermatocytic and maturation arrest, and Sertoli cell only (SCO) testes. Increased claudin-11 immunoreactivity was observed at the inter-Sertoli tight junctions in maturation arrest and in the cytoplasm of Sertoli cells in SCO. The late spermatogenic wave may negatively regulate claudin-11 gene activation and the subcellular localization of claudin-11 in Sertoli cells, thus altering the BTB in the human testis.
키워드
Claudin-11; human; Sertoli cells; testis; tight junction; SERTOLI-CELL; MOUSE TESTIS; BARRIER; PERMEABILITY; ANDROGENS; IMMATURE; OCCLUDIN; MEN
- 제목
- Claudin-11 expression increased in spermatogenic defect in human testes
- 저자
- Nah, Won Heum; Lee, Jae Eun; Park, Hyun Jun; Park, Nam Cheol; Gye, Myung Chan
- 발행일
- 2011-01
- 유형
- Editorial Material
- 권
- 95
- 호
- 1
- 페이지
- 385 ~ 388