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초록
We here report that doxycycline, an antibacterial agent, exerts dramatic effects on human embryonic stem and induced pluripotent stem cells (hESC/iPSCs) survival and self-renewal. The survival-promoting effect was also manifest in cultures of neural stem cells (NSCs) derived from hESC/iPSCs. These doxycycline effects are not associated with its antibacterial action, but mediated by direct activation of a PI3K-AKT intracellular signal. These findings indicate doxycycline as a useful supplement for stem cell cultures, facilitating their growth and maintenance.
키워드
DOPAMINE NEURONS; IN-VITRO; MICROGLIAL ACTIVATION; NEURAL PRECURSORS; HUMAN BLASTOCYSTS; RAT MODEL; DIFFERENTIATION; MINOCYCLINE; DERIVATION; ISCHEMIA
- 제목
- Doxycycline Enhances Survival and Self-Renewal of Human Pluripotent Stem Cells
- 저자
- Chang, Mi-Yoon; Rhee, Yong-Hee; Yi, Sang-Hoon; Lee, Su-Jae; Kim, Rae-Kwon; Kim, Hyongbum; Park, Chang-Hwan; Lee, Sang-Hun
- 발행일
- 2014-08
- 유형
- Article
- 권
- 3
- 호
- 2
- 페이지
- 353 ~ 364