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A high throughput and high content analysis of cell death processes using microfluidic image cytometry(μFIC)
- Yoo, Hyun Ju;
- Park, Jong Hoon;
- Kim, Min Jung;
- Lim, Kook Hee;
- Nho, Hyun Woo;
- ... Yoon, Tae Hyun;
- 외 1명
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SCOPUS
0초록
Microfluidic systems have significant implications in the field of in vitro cell-based assays and drug screening by virtue of their automation and high content screening capabilities. Here, we present our recent efforts to develop a microfluidic platform for high throughput and high content analysis of cell death event. A group of microfluidic devices for monitoring various cell death parameters was designed, fabricated and applied for the cytotoxicity assay of various toxicants. Particularly, the benefits of microfluidic image cytometry (μFIC), such as improvements in assay throughput, reduction in sample volume and labor-intensive manual operations, over conventional cell-based assay platforms (e.g., FACS) were discussed.
키워드
μFIC; Apoptosis; Cell death; Cytotoxicity; High content screening; High throughput assay; Microfluidic image cytometry; Cytotoxicity assays; High content analysis; High-content screening; High-throughput assays; Image cytometry; Micro fluidic system; Micro-fluidic devices; Microfluidic platforms; Assays; Cytotoxicity; Fluidic devices; Microfluidics; Throughput; Cell death
- 제목
- A high throughput and high content analysis of cell death processes using microfluidic image cytometry(μFIC)
- 저자
- Yoo, Hyun Ju; Park, Jong Hoon; Kim, Min Jung; Lim, Kook Hee; Nho, Hyun Woo; Rhee, Seog Woo; Yoon, Tae Hyun
- 발행일
- 2010-10
- 유형
- Conference Paper
- 저널명
- 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
- 권
- 1
- 페이지
- 250 ~ 252