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초록
Metformin is the most widely used anti-diabetic drug in the world. Recent evidence indicates that metformin could potentially inhibit tumorigenesis. In the present study, we found that metformin inhibited cell migration and invasion of phorbol 12-myristate 13-acetate-induced MCF-7 and tamoxifen-resistant MCF-7 breast cancer cells. This inhibition was correlated with the modulation of matrix metalloproteinase-9 (MMP9) via the suppression of its expression and proteolytic activity. These results indicate that metformin leads to the suppression of migration and invasion through regulation of MMP9 and it may have potential as an anticancer drug for therapy in human breast cancer, especially of chemoresistant cancer cells.
키워드
Metformin; MMP9; tamoxifen resistance; invasion; migration; MATRIX METALLOPROTEINASES; GELATINASE-B; MATRIX-METALLOPROTEINASE-9; EXPRESSION; METASTASIS; MECHANISMS; INVASION; GROWTH; ACTIVATION; PATHWAY
- 제목
- Metformin Inhibits Tumor Cell Migration via Down-regulation of MMP9 in Tamoxifen-resistant Breast Cancer Cells
- 저자
- Jang, Soon Young; Kim, Aeree; Kim, Jin Kyoung; Kim, Chungyel; Cho, Youl-Hee; Kim, Jong-Ho; Kim, Chul Hwan; Lee, Ji-Yun
- 발행일
- 2014-08
- 유형
- Article
- 권
- 34
- 호
- 8
- 페이지
- 4127 ~ 4134