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The Effect of Conjugating RGD into 3D Alginate Hydrogels on Adipogenic Differentiation of Human Adipose-Derived Stromal Cells
- Kang, Sun-Woong;
- Cha, Byung-Hyun;
- Park, Honghyun;
- Park, Kwang-Sook;
- Lee, Kuen Yong;
- 외 1명
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65Citations
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65초록
The effects of RGD peptide conjugation to alginate hydrogel on the adipogenic differentiation of ASCs was investigated. After 3 d of culture, RGD-modified alginate hydrogels significantly stimulated FAK and integrin alpha 1 gene expressions and vinculin expression in ASCs. In addition, RGD-modified alginate hydrogels significantly enhanced the adipogenic differentiation of human ASCs to exhibit higher expression levels of oil red O staining and adipogenic genes compared to those of the control group (unmodified gels). These results suggest potential applications of RGD-modified alginate gels for adipose tissue regeneration.
키워드
adhesion; biological applications of polymers; biomaterials; hydrogels; tissue engineering; ADHESION; PEPTIDE; INTEGRINS; CULTURE
- 제목
- The Effect of Conjugating RGD into 3D Alginate Hydrogels on Adipogenic Differentiation of Human Adipose-Derived Stromal Cells
- 저자
- Kang, Sun-Woong; Cha, Byung-Hyun; Park, Honghyun; Park, Kwang-Sook; Lee, Kuen Yong; Lee, Soo-Hong
- 발행일
- 2011-05
- 유형
- Article
- 권
- 11
- 호
- 5
- 페이지
- 673 ~ 679
- 언어
- ENG
- 출판사
- WILEY-V C H VERLAG GMBH
- 발행국가
- 독일
- 분량
- 7 페이지
- ISSN
- E 1616-5195
P 1616-5187