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Metal-Free C-H Amination for Indole Synthesis
- Jang, Young Ho;
- Youn, So Won
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104초록
An effective metal-free C-H amination of N-Ts-2-alkenylanilines by using DDQ as an oxidant has been developed to afford a diverse range of substituted indoles. This protocol is operationally simple and robust, obviates the need of expensive transition-metal catalysts, and offers a broad substrate scope. A mechanism involving a radical cation generated by SET and a migratorial process via a phenonium ion intermediate is proposed.
키워드
PALLADIUM-CATALYZED REACTIONS; 2,3-DICHLORO-5,6-DICYANO-1,4-BENZOQUINONE DDQ; 4-SUBSTITUTED INDOLES; HIGHLY EFFICIENT; PHENONIUM ION; OXIDATION; FUNCTIONALIZATION; CONVENIENT; ARYLPROPENES; HETEROCYCLES
- 제목
- Metal-Free C-H Amination for Indole Synthesis
- 저자
- Jang, Young Ho; Youn, So Won
- 발행일
- 2014-07
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 16
- 호
- 14
- 페이지
- 3720 ~ 3723