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Enhanced Self-Renewal and Accelerated Differentiation of Human Fetal Neural Stem Cells Using Graphene Oxide Nanoparticles
- Kim, Jin;
- Yang, Kisuk;
- Lee, Jong Seung;
- Hwang, Yong Hwa;
- Park, Hyun-Ji;
- ... Lee, Dong Yun;
- 외 2명
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31초록
Graphene oxide (GO) has received increasing attention in bioengineering fields due to its unique biophysical and electrical properties, along with excellent biocompatibility. The application of GO nanoparticles (GO-NPs) to engineer self-renewal and differentiation of human fetal neural stem cells (hfNSCs) is reported. GO-NPs added to hfNSC culture during neurosphere formation substantially promote cell-to-cell and cell-to-matrix interactions in neurospheres. Accordingly, GONP-treated hfNSCs show enhanced self-renewal ability and accelerated differentiation compared to untreated cells, indicating the utility of GO in developing stem cell therapies for neurogenesis.
키워드
differentiation; graphene oxide nanoparticle; neural stem cell; self-renewal; OSTEOGENIC DIFFERENTIATION; OXIDATIVE STRESS; THERAPY; SCAFFOLD; SURVIVAL; CONTACT; NEURONS; CANCER; NICHE
- 제목
- Enhanced Self-Renewal and Accelerated Differentiation of Human Fetal Neural Stem Cells Using Graphene Oxide Nanoparticles
- 저자
- Kim, Jin; Yang, Kisuk; Lee, Jong Seung; Hwang, Yong Hwa; Park, Hyun-Ji; Park, Kook In; Lee, Dong Yun; Cho, Seung-Woo
- 발행일
- 2017-08
- 유형
- Article
- 권
- 17
- 호
- 8