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C-H Activation: A Complementary Tool in the Total Synthesis of Complex Natural Products
- Chen, David Y. -K.;
- Youn, So Won
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496초록
The recent advent of transition-metal mediated C?H activation is revolutionizing the synthetic field and gradually infusing a C?H activation mind-set in both students and practitioners of organic synthesis. As a powerful testament of this emerging synthetic tool, applications of C?H activation in the context of total synthesis of complex natural products are beginning to blossom. Herein, recently completed total syntheses showcasing creative and ingenious incorporation of C?H activation as a strategic manoeuver are compared with their non-C?H activation counterparts, illuminating a new paradigm in strategic synthetic design.
키워드
C-H activation; natural products; synthetic methods; total synthesis; transition metals; CROSS-COUPLING REACTIONS; N BOND FORMATION; WATER MARINE SPONGE; HIGHLY ENANTIOSELECTIVE HYDROGENATION; ASYMMETRIC INTRAMOLECULAR ALKYLATION; STEREOCONTROLLED TOTAL-SYNTHESIS; PUMMERER REACTION CHEMISTRY; ALPHA-DEHYDROAMINO ACIDS; DRAGMACIDIN-E SYNTHESIS; FORMAL TOTAL-SYNTHESIS
- 제목
- C-H Activation: A Complementary Tool in the Total Synthesis of Complex Natural Products
- 저자
- Chen, David Y. -K.; Youn, So Won
- 발행일
- 2012-07
- 유형
- Review
- 권
- 18
- 호
- 31
- 페이지
- 9452 ~ 9474