A capacitive biosensor using buried electrodes for the discrimination of whole-cells

Kim, Kyubeom Kim; Yunheub Song; Song, Yunheub

doi:10.1109/TENCON.2014.7022305

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A capacitive biosensor using buried electrodes for the discrimination of whole-cells

Kim, Kyubeom Kim; Yunheub Song;
Song, Yunheub

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초록

This paper presents a capacitive biosensor that measures capacitances of living cells in electrolytic solution. The capacitive sensor was designed to consist of buried electrodes and was fabricated in Complementary Metal-Oxide-Semiconductor (CMOS) technology. Normal breast tissue cell MCF-10A, invasive breast cancer cell MDA-MB-231, and early-stage breast cancer cell MCF-7 were prepared. The capacitances of three cells were measured by LCR meter and calculated the capacitance differences from controlled experiment. Our results show that the capacitance changes of normal and breast cancer cells are different at whole-cell level. Furthermore, the capacitive difference of the cancer cells was observed by stage of cancer. This characterization may have useful developments for applications such as cancer diagnosis and treatment.

키워드

Biomedical transducers; biosensors; capacitance transducers; Biosensors; Capacitance; CMOS integrated circuits; Diseases; Electrodes; Metals; MOS devices; Oxide semiconductors; Transducers; Biomedical transducers; Breast cancer cells; Capacitance transducers; Capacitive biosensors; Complementary metal-oxide-semiconductor technologies; Controlled experiment; Early-stage breast cancer; Electrolytic solution; Capacitive sensors

제목: A capacitive biosensor using buried electrodes for the discrimination of whole-cells

저자: Kim, Kyubeom Kim; Yunheub Song; Song, Yunheub

DOI: 10.1109/TENCON.2014.7022305

발행일: 2015-01

유형: Conference Paper

저널명: IEEE Region 10 Annual International Conference, Proceedings/TENCON

권: 2015-January

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