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Zinc-Catalyzed Transacetalization of N, O -Acetals into N, N -Acetals with Benzotriazoles, Indazoles, and Azides
- Shin, Sang Ik;
- Nguyen, Nguyen H.;
- Im, Jangbin;
- Shin, Seunghoon
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WEB OF SCIENCE
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4초록
N , O -Acetals obtained from beta-oxidation of ynamides underwent transacetalization with benzotriazoles, leading to N , N -acetals. The Zn(OTf) (2) efficiently catalyzed the process, and the reaction is further accelerated in hexafluoroisopropanol, providing a single N1-regiosiomer. The transacetalization conditions developed could be extended to other N-donors, such as 1 H -indazole and TMSN (3) to afford the corresponding N , N -acetals.
키워드
Zn catalysis; transacetalization; N; N; -acetal; ynamide; benzotriazole; azide; benzotriazole derivative; indazole derivative; n,n acetal derivative; n,o acetal derivative; unclassified drug; zinc; Article; catalysis; chemical analysis; chemical modification; chemical reaction; chemical structure; concentration (parameter); oxidation; process optimization; temperature measurement; transacetalization
- 제목
- Zinc-Catalyzed Transacetalization of N, O -Acetals into N, N -Acetals with Benzotriazoles, Indazoles, and Azides
- 저자
- Shin, Sang Ik; Nguyen, Nguyen H.; Im, Jangbin; Shin, Seunghoon
- 발행일
- 2021-03
- 유형
- Article
- 저널명
- Synlett
- 권
- 32
- 호
- 05
- 페이지
- 521 ~ 524
- 언어
- ENG
- 출판사
- GEORG THIEME VERLAG KG
- 발행국가
- 독일
- 분량
- 4 페이지
- ISSN
- E 1437-2096
P 0936-5214