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N-Arylation of Sterically Hindered NH-Nucleophiles: Copper-Mediated Syntheses of Diverse N-Arylindole-2-carboxylates
- Lee, Jinyong;
- Choi, Ji Hye;
- Shin, Seunghoon;
- Heo, Jung-Nyoung;
- Lim, Hwan Jung
Citations
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5초록
Indole-carboxylates are N-arylated with 2-bromopyridines using stoichiometric copper(II) oxide/potassium carbonate to give various N-(2-pyridyl)-substituted indole-2-carboxylates and with bromobenzenes using stoichiometric copper(I) iodide/N,N'-dimethylethylenediamine to give various N-(substituted phenyl)-substituted indole-2-carboxylates. These results expand the scope of metal-catalyzed N-arylation using heterocyclic amines with steric bulk and weak nucleophilicity.
키워드
copper; N-arylation; indoles; copper-mediated synthesis; heterocyclic amines; metal-catalyzed; CROSS-COUPLING REACTIONS; NITROGEN-CONTAINING HETEROCYCLES; C-N; FISCHER INDOLIZATION; ARYL HALIDES; INDOLES; PALLADIUM; EFFICIENT; ULLMANN; DERIVATIVES
- 제목
- N-Arylation of Sterically Hindered NH-Nucleophiles: Copper-Mediated Syntheses of Diverse N-Arylindole-2-carboxylates
- 저자
- Lee, Jinyong; Choi, Ji Hye; Shin, Seunghoon; Heo, Jung-Nyoung; Lim, Hwan Jung
- 발행일
- 2015-11
- 유형
- Article
- 저널명
- Synthesis
- 권
- 47
- 호
- 21
- 페이지
- 3301 ~ 3308
- 언어
- ENG
- 출판사
- GEORG THIEME VERLAG KG
- 발행국가
- 독일
- 분량
- 8 페이지
- ISSN
- E 1437-210X
P 0039-7881