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Transition-Metal-Catalyzed Annulative Coupling Cascade for the Synthesis of 3-Methyleneisoindolin-1-ones
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16초록
This short review describes the recent progress made on transition-metal-catalyzed annulative couplings for the synthesis of 3-methyleneisoindolin-1-ones, which are useful intermediates for the synthesis of numerous alkaloids and can be often found in a wide range of natural products and pharmaceuticals. In particular, new one-pot multiple C-C/C-N bond-forming processes for the construction of the 5-methylenepyrrol-2-one nucleus of such compounds are summarized.
키워드
N-heterocycles; isoindolinones; transition-metal catalysis; C-H functionalization; cascade reactions; cyclizations; coupling reactions; C-H ACTIVATION; NITROGEN-CONTAINING HETEROCYCLES; POSSESSING INHIBITORY-ACTIVITY; MIYAURA DOMINO REACTIONS; 1ST TOTAL-SYNTHESIS; ONE-POT SYNTHESIS; N BOND FORMATION; STEREOSELECTIVE-SYNTHESIS; EFFICIENT SYNTHESIS; HIGHLY REGIO
- 제목
- Transition-Metal-Catalyzed Annulative Coupling Cascade for the Synthesis of 3-Methyleneisoindolin-1-ones
- 저자
- Youn, So Won
- 발행일
- 2020-03
- 유형
- Review
- 저널명
- Synthesis
- 권
- 52
- 호
- 6
- 페이지
- 807 ~ 818